The levels of the long non-coding RNA MALAT1 affect cell viability and modulate TDP-43 binding to mRNA in the nucleus.

TAR DNA-binding protein (TDP-43) and Metastasis Associated Lung Adenocarcinoma Transcript (MALAT1) RNA are both abundantly expressed in the human cell nucleus. Increased interaction of TDP-43 and MALAT1, as well as dysregulation of TDP-43 function, was previously identified in brain samples from patients with neurodegenerative disease compared to healthy brain tissues. We hypothesized that TDP-43 function may depend in part on MALAT1 expression levels.

A Rare Presentation of Disseminated Peritoneal Leiomyomatosis Following Laparoscopic Hysterectomy and Its Multidisciplinary Management.

Disseminated peritoneal leiomyomatosis (DPL) is a rare entity. It is a benign disease but can mimic disseminated malignancy with extensive disease at multiple sites within the abdominopelvic cavity. The primary contributing factor is postulated to be peritoneal spillage of benign leiomyoma, especially after laparoscopic intervention, although hormonal influences might also play a role.

Right Ventricular Myxoma Involving the Chordae Tendineae: A Case Report and Literature Review.

This case report describes a rare instance of massive right ventricular myxoma (RVM). A 36-year-old woman initially presented with progressive breathlessness and chest heaviness. Imaging revealed a large mass in the mediastinum, which was initially thought to be a pericardial cyst, and it was unclear whether the mass was intracardiac or extracardiac.

Achieving Clinical Success in Root Coverage and Aesthetic Improvement by Using Subepithelial Connective Tissue Grafts: A Report of Two Cases.

Over the years, several modalities have been established to treat gingival recession. Nonetheless, subepithelial connective tissue grafts (SECTGs) remain a dependable technique for root coverage, mainly due to their superior vascularization. However, the procurement of the CTG is susceptible to technique sensitivity; consequently, various methodologies have emerged to harvest CTGs to mitigate donor site trauma.

A Rare Case of Solitary Fibrous Tumor Originating in the Peritoneum: Clinical and Histopathological Insights.

Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms that most commonly arise from the pleura, with peritoneal origin being exceptionally uncommon. We report a case of a 51-year-old male who presented with a large abdominal mass, subsequently diagnosed as a solitary fibrous tumor originating from the peritoneum. Radiological evaluation revealed a well-defined mass with a vascular pedicle supplied by the inferior mesenteric artery, extending from the pelvis to the lower abdomen.