Publications by authors named "A Sahar"
Purpose: Polycystic ovary syndrome (PCOS) is an endocrine disorder with the highest prevalence among other disorders in sexually-active women. It is associated with broad-spectrum hormonal and metabolic disturbances with behavioural difficulties. Experimentally, letrozole administration causes similar findings.
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- - Licorice is a key herb in traditional Chinese medicine noted for its anti-inflammatory properties, thanks to its ability to inhibit inflammatory pathways and prevent activation of key inflammatory markers like TNF-α and IL-6.
- - Its bioactive compounds, such as glycyrrhetinic acid and liquiritigenin, play a crucial role by interfering with processes in the MAPK and NF-κB signaling pathways, which are vital in regulating inflammation.
- - Ongoing research aims to delve deeper into the molecular mechanisms of licorice's effects, enhancing its potential as a natural treatment for inflammatory disorders and exploring ways to improve its applications in clinical settings.
Chemobrain is a cognitive impairment observed in up to 75% of cancer patients treated with doxorubicin (DOX). Cognitive deficits associated with DOX are complex, and multiple interplay pathways contribute to memory impairment and the loss of concentration. Empagliflozin (EMPA), a sodium-glucose co-transporter-2 (SGLT-2) inhibitor with neuroprotective potential, has recently been elucidated because of its regulatory effects on oxidative stress and neuroinflammation.
View Article and Find Full Text PDFAs a severe neurological disorder, Parkinson's disease (PD) is distinguished by dopaminergic neuronal degeneration in the substantia nigra (SN), culminating in motor impairments. Several studies have shown that activation of the AMPK/SIRT1/PGC1α pathway contributes to an increase in mitochondrial biogenesis and is a promising candidate for the management of PD. Furthermore, turning on the AMPK/SIRT1/PGC1α pathway causes autophagy activation, which is fundamental for maintaining neuronal homeostasis.
View Article and Find Full Text PDFBackground: Poultry processing generates a large amount of industrial waste, which is rich in collagen content. This waste can be utilized for the extraction of valuable components such as gelatin, which can be used as an alternative to mammalian gelatin (porcine and bovine).
Results: Gelatins were analyzed for their yield, proximate analysis, pH, color, viscosity, bloom strength, and texture profile analysis.