Publications by authors named "A Saglietto"

Brugada syndrome (BrS) is a genetic condition that increases the risk of life-threatening arrhythmias, which can result in sudden cardiac death (SCD). Implantable loop recorders (ILRs) have become a key tool in managing patients with unexplained syncope, and guidelines advise their use in individuals with recurrent, unexplained syncope or palpitations. However, the role of ILRs in inherited arrhythmic conditions like BrS remains a topic of debate.

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Background: Cardioneuroablation (CNA) treats reflex syncope by ablating ganglionated plexi (GPs) either confined to the right (RA) or left atrium (LA), or accessible from both. We assessed whether GP ablation in one atrium affects parasympathetic modulation in the other and how ablation sequence (RA then LA, or vice-versa) impacts efficacy.

Methods: Two propensity-matched groups of patients with reflex syncope or functional bradycardia were analyzed.

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Background: Despite evidence supporting use of fractional flow reserve (FFR) and instantaneous waves-free ratio (iFR) to improve outcome of patients undergoing coronary angiography (CA) and percutaneous coronary intervention, such techniques are still underused in clinical practice due to economic and logistic issues.

Objectives: We aimed to develop an artificial intelligence (AI)-based application to compute FFR and iFR from plain CA.

Methods And Results: Consecutive patients performing FFR or iFR or both were enrolled.

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Article Synopsis
  • Identifying effective strategies to protect the heart from damage during procedures related to ischemia/reperfusion (I/R) injury is crucial, as past interventions often failed in clinical settings.
  • The review highlights the use of cervical vagal nerve stimulation (cVNS) and transcutaneous auricular vagus nerve stimulation (taVNS) as promising neuromodulation techniques to reduce sympathetic nervous system activity and enhance vagal tone.
  • Evidence from pre-clinical studies supports the cardioprotective effects of VNS in both acute and chronic cardiac injuries, suggesting that timely application of these techniques improves outcomes significantly.
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