Practical implementation of automated insulin delivery systems in 2025: A French position statement update.

The advent of automated insulin delivery (AID) systems in 2020 marked a disruptive event in managing type 1 diabetes, benefiting children and adults alike. By 2024, advances in real-world data and research motivated an update to the French consensus on AID systems to expand accessibility, refine guidelines, and optimize patient follow-up. AID systems have consistently improved glycemic control by reducing HbA1c, increasing time-in-range (TIR), and minimizing hypoglycemia, with significant benefits even for specific populations such as individuals with poor glycemic control, brittle diabetes, children, very young children, pregnant women, those with insulin resistance or gastroparesis, or after bariatric surgery.

Deciphering the Competitive Charge Storage Chemistry of Metal Cations and Protons in Aqueous MnO-Based Supercapacitors.

The complex charge storage mechanisms in aqueous MnO-based supercapacitors have posed significant challenges to a comprehensive understanding of their chemical behavior. In this study, we employed Au-core@MnO-shell nanoparticle-enhanced Raman spectroscopy, alongside electrochemical analysis and X-ray absorption, to systematically investigate the competitive charge storage chemistry of protons and cations within the inner and outer layers of δ-MnO under alkaline conditions. Our findings reveal that δ-MnO operates through a dual mechanism: the intercalation and deintercalation of metal cations dominate charge storage in the inner layer, while surface chemisorption of protons governs the outer layer.

Early β-Blocker Use and Clinical Outcomes in Acute Myocardial Injury: A Retrospective Cohort Study.

Background: Acute myocardial injury is defined by elevated cardiac troponin (cTn) levels with a rising and/or falling pattern, and is associated with increased mortality risk compared to patients without myocardial injury. The role of β-blockers in patients with acute myocardial injury remains unclear.

Methods: This multicenter, retrospective cohort study used data from the Tianjin Health and Medical Data Platform to assess the impact of early β-blocker use on 1-year all-cause mortality and major adverse cardiovascular events (MACE) in acute myocardial injury patients, employing a new user and target trial emulation design.

Multi-omics informed mathematical model for meropenem and tobramycin against hypermutable Pseudomonas aeruginosa.

Hypermutable P. aeruginosa isolates frequently display resistance emergence during treatment. Mechanisms of such resistance emergence have not been explored using dynamic hollow-fiber studies and multi-omics-informed mathematical modeling.