Publications by authors named "A Sadakane"
The use of organic solvents in drug delivery systems (DDSs) either to produce albumin nanoparticles or to manipulate the binding of target molecules to albumin, a promising nanocarrier material, presents challenges due to the conformational changes induced in the protein. In this study, we investigated the alterations in the conformation of bovine serum albumin (BSA) caused by acetonitrile (ACN) in aqueous solution by using a combination of spectroscopic analysis and molecular dynamics (MD) simulations. Ultraviolet (UV) absorption, fluorescence, and infrared (IR) absorption spectroscopy were used to analyze the BSA conformation in the solutions containing 0-60 vol % ACN.
View Article and Find Full Text PDFBackground: This study was performed to investigate the association between body mass index (BMI) and gastric cancer in East and Southeast Asia where most of gastric cancer is non-cardia gastric cancer.
Methods: On the basis of 8,997 gastric cancer cases among the Asia Cohort Consortium participants from China, Japan, Korea, and Singapore (N = 538,835), we assessed gastric cancer risk according to BMI by calculating hazard ratios (HR) and 95% confidence intervals (CI) using the Cox proportional hazard regression model.
Results: A U-shaped associations between BMI and gastric cancer risk were observed.
Article Synopsis
- A study investigated the link between body mass index (BMI) and oesophageal cancer (OC) mortality among over 842,000 Asians, highlighting notable differences compared to research on Europeans and North Americans.
- The analysis revealed a wide J-shaped association where both underweight individuals (BMI < 18.5) and those with extreme obesity (BMI ≥ 35) faced a significantly higher risk of OC mortality compared to the normal BMI range (23-25).
- Additionally, the research showed that smoking and alcohol consumption further heightened OC mortality risk for underweight participants, indicating a complex relationship between lifestyle factors, BMI, and cancer outcomes.
Article Synopsis
- The study investigates how mortality rates change over time after quitting smoking among Asian populations, noting distinct smoking behaviors compared to Westerners.
- Analyzing data from over 709,000 participants across 16 cohorts in Asia, the research reveals a gradual reduction in mortality from all causes, cardiovascular disease (CVD), and lung cancer with increased years since quitting, but elevated risks persist even 10-14 years post-cessation.
- Findings indicate that former smokers, particularly heavy smokers, face long-term heightened mortality risks, with significant implications for clinical guidelines regarding lung cancer and CVD risk assessments.
Although previous meta-analyses have suggested a dose-response relationship between body mass index (BMI) and thyroid cancer risk, limited evidence has been presented about Asian populations. To assess this association among Asian populations, where underweight is more prevalent than in other regions, a pooled analysis from the Asia Cohort Consortium was conducted. Baseline height and weight were measured in five cohorts and self-reported in eight cohorts.
View Article and Find Full Text PDF