Publications by authors named "A Sacharuk"
Article Synopsis
- 7-Nitroindazole (7NI), a nitric oxide synthase inhibitor, increased the seizure threshold in mice when administered at various doses (50-200 mg/kg) before electroconvulsion tests, specifically showing a 50% increase at 115.2 mg/kg and 100% at 173.4 mg/kg.
- It enhanced the anticonvulsant effects of traditional antiepileptic drugs like phenobarbital and phenytoin, most effectively at a higher dose of 150 mg/kg, while lower doses influenced only specific drugs and not carbamazepine.
- Co-administration of L-arginine, a natural precursor of nitric oxide, with 7NI significantly
The authors, expecting confirmation of arrhythmogenic effects of work at the Intensive Cardiological Care Unit (ICCU), recorded a 24-hour ECG in the employed staff. Together 20 healthy individuals (mean age 31.6 years) were tested.
View Article and Find Full Text PDFAuthors performed comparative measurements of cardiac output using the impedance rheography and Fick's method in healthy men (6) reaching the value of correlation coefficient 0.88 and in patients with acquired cardiac defects (n = 21; r = 0.68).
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