From Alzheimer's Disease to Anxiety, Epilepsy to Schizophrenia: A Comprehensive Dive Into Neuro-Psychiatric Disorders.

This comprehensive narrative review endeavors to dissect the intricate web of neuropsychiatric disorders that significantly impact cognition, emotion regulation, behavior, and mental health. With a keen focus on Alzheimer's disease (AD), anxiety disorders, epilepsy, schizophrenia, and autism spectrum disorder (ASD), this article delves into their underlying mechanisms, clinical presentations, diagnostic challenges, and therapeutic interventions. Highlighting the considerable disability and societal costs that these conditions impose, it reflects on the over six million individuals grappling with Alzheimer's, the 19 million American adults living with anxiety disorders, the three million with epilepsy, and the global reach of schizophrenia affecting approximately 20 million people.

BI-RADS-Based Classification of Mammographic Soft Tissue Opacities Using a Deep Convolutional Neural Network.

The aim of this study was to investigate the potential of a machine learning algorithm to classify breast cancer solely by the presence of soft tissue opacities in mammograms, independent of other morphological features, using a deep convolutional neural network (dCNN). Soft tissue opacities were classified based on their radiological appearance using the ACR BI-RADS atlas. We included 1744 mammograms from 438 patients to create 7242 icons by manual labeling.

A Candidate RNAi Screen Reveals Diverse RNA-Binding Protein Phenotypes in Flight Muscle.

The proper regulation of RNA processing is critical for muscle development and the fine-tuning of contractile ability among muscle fiber-types. RNA binding proteins (RBPs) regulate the diverse steps in RNA processing, including alternative splicing, which generates fiber-type specific isoforms of structural proteins that confer contractile sarcomeres with distinct biomechanical properties. Alternative splicing is disrupted in muscle diseases such as myotonic dystrophy and dilated cardiomyopathy and is altered after intense exercise as well as with aging.

[Laryngeal mask as alternative to facial mask in the newborn].

Objective: The present study demonstrates that the use of laryngeal mask airway (LMA) is an alternative to face-mask (FM) during induction of general anesthesia with halothane. In all patient the induction of general anesthesia is carried out by halotane and N2O/O2 50%, using only the LMA, preceding topical anesthesia of pharynx.

Experimental Design: prospective study.