Publications by authors named "A Sabag"
Importance: Although prolonged fasting has become increasingly popular, the favourable biological adaptations and possible adverse effects in humans have yet to be fully elucidated.
Objective: To investigate the effects of a three-day water-only fasting, with or without exercise-induced glycogen depletion, on autophagy activation and the molecular pathways involved in cellular damage accumulation and repair in healthy humans.
Design: A randomised, single-centre, two-period, two-sequence crossover trial.
Background: Vigorous intermittent lifestyle physical activity (VILPA) refers to brief bouts of intense physical activity embedded into daily life.
Objective: To examine sex differences in the dose-response association of VILPA with major adverse cardiovascular events (MACE) and its subtypes.
Methods: Using multivariable-adjusted cubic splines, we examined the associations of daily VILPA duration with overall MACE and its subtypes (incident myocardial infarction, heart failure and stroke) among non-exercisers (individuals self-reporting no leisure-time exercise and no more than one recreational walk per week) in the UK Biobank.
Article Synopsis
- The study aimed to explore how consistent sleep patterns (measured by the Sleep Regularity Index) influence the risk of developing type 2 diabetes (T2D) in adults aged 40-79.
- Researchers tracked 73,630 individuals over 8 years, finding that those with irregular sleep patterns were at a higher risk of T2D than regular sleepers, regardless of getting the recommended sleep duration.
- The findings suggest that promoting consistent sleep schedules is essential, as simply meeting sleep duration guidelines does not mitigate the negative impact of irregular sleep on T2D risk.
Objectives: This study aimed to evaluate the effects of a novel, low-volume combined high-intensity interval training (HIIT) and progressive resistance training (PRT) in overweight/obese adults.
Methods: This randomised control trial compared the effect of regular supervised HIIT combined with PRT (Exercise) with an unsupervised stretching intervention (Control), in previously inactive adults with either normal glucose (NG), pre-diabetes or type 2 diabetes (T2DM) with body mass index of >25 kg/m. Participants were randomly allocated (1:1) to receive low-volume exercise or control by an online randomisation tool.
Aims: Incidental physical activity as part of daily living may offer feasibility advantages over traditional exercise. We examined the joint associations of incidental physical activity and sedentary behaviour with major adverse cardiovascular events (MACE) risk.
Methods And Results: Analyses included 22 368 non-exercising adults from the UK Biobank accelerometry sub-study (median age [IQR]: 62.