Publications by authors named "A SCHAUER"
A Cross-Biomeasure Study to Optimize Antiretroviral Adherence Estimation.
J Acquir Immune Defic Syndr
November 2024
Background: Incomplete adherence to daily tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) reduces effectiveness. Adherence biomeasures (i.e.
View Article and Find Full Text PDFAims: ZSF1 obese rats harbouring two mutant leptin receptor alleles (Lepr and Lepr) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research. Studies using ZSF1 rats have contributed significantly to the elucidation of pathophysiological mechanisms underlying HFpEF and therapeutic strategies against this multi-organ syndrome. In contrast, hybrid, lean ZSF1 rats (L-ZSF1) do not develop HFpEF and generally serve as controls, disregarding the possibility that the presence of one mutant Lepr allele might affect left ventricular ejection fraction (LVEF), diastolic dysfunction and other relevant HFpEF parameters, such as N-terminal pro-brain natriuretic peptide (NT-proBNP) levels and cardiac inflammation, which could increase during disease manifestation.
View Article and Find Full Text PDFArticle Synopsis
- * The study introduces a 3D printed multipurpose prevention technology (MPT) intravaginal ring (IVR) designed to prevent HIV, HSV-2, and unintended pregnancy, utilizing advanced 3D printing techniques and biocompatible materials.
- * The IVRs demonstrated stable drug release and safety in macaque studies, maintaining effectiveness and tolerability over a 28-day period without causing any significant inflammatory responses.