Angiogenesis plays a crucial role in tumor development and is a driving force for the aggressiveness of several types of cancer. Our team developed a novel series of thiosemicarbazone-containing quinazoline derivatives, , as potential VEGFR2 inhibitors with proven anti-angiogenic and antiproliferative potential. : The series was synthesized and characterized by spectral data.
View Article and Find Full Text PDFRodents (Mammalia: Rodentia) are among the ubiquitous hosts of Giardia duodenalis, as they can harbour at least six assemblages of this species, including the zoonotic assemblages A and B. However, studies targeting a broad spectrum of rodents and rabbits sampled in the same region are scarce, even in Europe. During this study, 164 samples were collected from five rodent species and rabbits in five locations in Hungary, to examine the presence of G.
View Article and Find Full Text PDFBackground: Patients undergoing bariatric surgery may be at increased risk for postsurgical opioid dependence, highlighting a need for opioid-sparing anesthesia.
Objectives: Liposomal bupivacaine (LB), a prolonged release formulation of bupivacaine, may improve postoperative pain management and reduce postsurgical opioid use. This retrospective claims-database study investigated the effects of LB versus non-LB analgesia on opioid use and healthcare resource utilization (HCRU) in patients receiving laparoscopic sleeve gastrectomy (SG).
Carotid artery stenosis (CAS) often requires surgical intervention through carotid endarterectomy (CEA) to prevent stroke. Accurate cerebrovascular risk assessments are crucial in CEA, as poor collateral circulation can lead to insufficient interhemispheric blood flow compensation, resulting in ischemic complications. Therefore, understanding perioperative risk determinants is vital.
View Article and Find Full Text PDFBackground: Potentially zoonotic pathogens have been previously detected in bat-associated ticks, but their role in disease transmission and their frequency of feeding on non-bat hosts is poorly known.
Methodology/principal Findings: We used molecular blood meal analysis to reveal feeding patterns of the bat-associated tick species Ixodes ariadnae, I. simplex, and I.