[Correction of cardiodynamic disorders in experimental diabetes by omega-3 polyunsaturated fatty acids].

In experiments on rat hearts in vivo with the system for pressure-volume registration "Millar Instruments" cardiodynamic disorders were studied in experimental diabetes for their correction with omega-3 polyunsaturated fatty acids (PUFAs). The application of omega-3 PUFAs in animals with diabetes may improve cardiodynamic parameters--pump and diastolic function.

[Study of the impact of omega-3 PUFA on fatty acid composition of heart, respiration and swelling of mitochondria of the heart in diabetes].

We studied the influence of omega-3 polyunsaturated fatty acids (PUFAs) on respiration, swelling of rat heart mitochondria and changes in rat heart fatty acid composition in tissue homogenate in rats with streptozotocin induced diabetes mellitus (diabetes), which was induced by single intraperitoneal administration of 55 mg/kg streptozotocin. We found that application of these acids increased parameters of active mitochondrial respiration V3 at 63.7%, controlled breathing V4 at 30.