[Development of Biological Microchips on an Aluminum Support with Cells Made of Brush Polymers].

A method has been developed for manufacturing biological microchips on an aluminum substrate with hydrophilic cells from brush copolymers with the formation of a matrix of cells using photolithography. The surface of aluminum substrates was previously coated with a thin, durable, moderately hydrophobic layer of cross-linked polymer to prevent contact with the aluminum surface of the components used in the analysis of nucleic acids. Aluminum biochip substrates have high thermal conductivity and low heat capacity, which is important for the development of methods for multiplex PCR analysis on a chip.

High- and Moderate-Risk Variants Among Breast Cancer Patients and Healthy Donors Enrolled in Multigene Panel Testing in a Population of Central Russia.

Assessments of breast cancer (BC) risk in carriers of pathogenic variants identified by gene panel testing in different populations are highly in demand worldwide. We performed target sequencing of 78 genes involved in DNA repair in 860 females with BC and 520 age- and family history-matched controls from Central Russia. Among BC patients, 562/860 (65.

Thermalization rate of polaritons in strongly-coupled molecular systems.

Polariton thermalization is a key process in achieving light-matter Bose-Einstein condensation, spanning from solid-state semiconductor microcavities at cryogenic temperatures to surface plasmon nanocavities with molecules at room temperature. Originated from the matter component of polariton states, the microscopic mechanisms of thermalization are closely tied to specific material properties. In this work, we investigate polariton thermalization in strongly-coupled molecular systems.

Sympathetic Mechanism for Vibrational Condensation Enabled by Polariton Optomechanical Interaction.

We demonstrate a macrocoherent regime in exciton-polariton systems, where nonequilibrium polariton Bose-Einstein condensation coexists with macroscopically occupied vibrational states. Strong exciton-vibration coupling induces an effective optomechanical interaction between cavity polaritons and vibrational degrees of freedom of molecules, leading to vibrational amplification in a resonant blue-detuned configuration. This interaction provides a sympathetic mechanism to achieve vibrational condensation with potential applications in cavity-controlled chemistry, nonlinear, and quantum optics.

Non-Hermitian dynamics and non-reciprocity of optically coupled nanoparticles.

Non-Hermitian dynamics, as observed in photonic, atomic, electrical and optomechanical platforms, holds great potential for sensing applications and signal processing. Recently, fully tuneable non-reciprocal optical interaction has been demonstrated between levitated nanoparticles. Here we use this tunability to investigate the collective non-Hermitian dynamics of two non-reciprocally and nonlinearly interacting nanoparticles.