Effect of alcoholic intoxication on water content and activity of Na,K-ATPase and Ca-ATPase in rat brain.

We studied the effect of 2-week alcohol intoxication on water exchange and activity of Na,K-ATPase and Ca-ATPase in rat brain. Alcohol intoxication increased water content in the brain due to cell hyperhydration. It is assumed that hyperhydration results from increased Na+ content in cells due to inhibition Na,K-ATPase activity, which in turn is caused by activation of lipid peroxidation under the effect of ethanol.

Function of Ca-pump in sarcoplasmic reticulum of rat myocardium during adaptation to electromagnetic field.

We studied the effect of adaptation to electromagnetic field on functional state of Ca-pump in sarcoplasmic reticulum, intensity of lipid peroxidation, and energy metabolism in rat myocardium. Membrane viscosity was assessed in crude preparation of myocardial sarcoplasmic reticulum. Adaptation to electromagnetic field did not change the rate of endogenous respiration, including ouabain-sensitive respiration, but potentiated coupling between catalytic activity and Ca-transporting capacity of Ca-pump.