Basic Science and Pathogenesis.

Background: Monoclonal antibodies have emerged as a leading therapeutic agent for the treatment of disease, including Alzheimer's disease. Such antibodies, however, are expensive and timely to produce and require frequent dosing regimens to ensure disease-modifying effects. Synthetic in vitro-transcribed mRNA encoding antibodies presents a promising alternative to conventional passive immunotherapy and overcomes the need to generate recombinant antibodies.

Ecomorphology of main food processing structures of four ocypodid species: how do they relate to the crabs' trophic habits?

The spoon-tipped (ST) setae coverage and their abundance on the second maxillipeds as well as the morphology of the urocardiac and zygocardiac ossicles from the gastric mills of the four ocypodid species, viz., Austruca annulipes (H. Milne Edwards, 1837), Gelasimus vocans (Linnaeus), 1758, two typical deposit-feeding fiddler crabs, Petruca panamensis (Stimpson, 1859), an atypical herbivorous-cum-'sediment swallower' fiddler crab, and Ocypode ceratophthalmus (Pallas, 1772), an omnivorous ghost crab, were described and compared in relation to their respective trophic habits.

Non-destructive viability assessment of cancer cell spheroids using dynamic optical coherence tomography with trypan blue validation.

3D cell cultures are widely used in biomedical research for the recapitulation of microenvironments. Viability assessment and monitoring of these intricate conformations remain an open problem as standard cell viability protocols based on colorimetry or microscopy are not directly applicable to intact 3D samples. Optical coherence tomography (OCT) has been explored extensively for subsurface structural and quasi-functional analysis of 3D cell cultures and tissue.

Correcting near vision impairment and women's empowerment: a before-after mixed-methods study among older Zanzibari craftswomen.

Objective: To understand if presbyopia correction could empower older craftswomen entrepreneurs living in Zanzibar.

Design: Mixed-method, before-after intervention study.

Setting: Unguja and Pemba islands, Zanzibar.

CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting.

Chronic myelomonocytic leukemia (CMML) is a rare blood cancer of older adults (3 in every 1,000,000 persons) characterized by poor survival and lacking effective mutation-specific therapy. Mutations in the ubiquitin ligase Cbl occur frequently in CMML and share biological and molecular features with a clonal disease occurring in children, juvenile myelomonocytic leukemia (JMML). Here we analyzed the clinical presentations, molecular features and immunophenotype of CMML patients with CBL mutations enrolled in a prospective Phase II clinical trial stratified according to molecular markers.