Publications by authors named "A S Volkmann"
Background: Health worker vaccination programmes can help to safeguard both health workers (HWs) and their patients and enhance vaccine uptake more broadly in local communities and society. This study's objective was to increase global understanding of how existing HW vaccination programmes were leveraged for emergency COVID-19 vaccine introduction.
Methods: This qualitative study included 13 in-depth group interviews with 38 key informants with expertise in vaccine programme implementation from eleven countries in five WHO regions: Albania, Armenia, Bhutan, Lao PDR, Maldives, Mongolia, Oman, Timor Leste, the United Kingdom, Vietnam, and Zimbabwe in addition to WHO regional focal points from all six regions.
Article Synopsis
- The study investigates the safety and effectiveness of a new vaccine, MVA-BN-WEV, designed to protect against three encephalitic alphaviruses (WEEV, EEEV, VEEV) in healthy adults.
- Forty-five participants were given two doses of the vaccine at varying strengths, monitored for side effects and immune response over six months.
- Results showed the vaccine was generally safe with mild side effects, and it successfully triggered strong immune responses against all three viruses, especially at higher doses.
Article Synopsis
- Researchers tested two vaccines for eastern equine encephalitis virus (EEEV) in cynomolgus macaques using an aerosol infection model.
- Both vaccines, MVA-BN-EEEV (monovalent) and MVA-BN-WEV (multivalent), triggered strong and lasting immune responses that protected the monkeys against lethal EEEV exposure.
- The results showed that the vaccinated macaques had nearly complete protection from viral presence in their bodies and no significant brain damage, suggesting the vaccines are effective against aerosolized EEEV infections.
Objectives: Delivered as part of the global assessment of diabetes in urban settings, this study explores different aspects of living with type 2 diabetes, for adults aged 18-40. Primary questions were as follows: (1) can we identify subgroups of adults under 40 years old sharing specific perspectives towards health, well-being and living with type 2 diabetes and (2) do these perspectives reveal specific barriers to and opportunities for better type 2 diabetes prevention and management and improved well-being?
Design: The study employed a mixed-method design with data collected through demographic questionnaires, Q-sort statement sorting exercises, focus groups discussions and individual interviews.
Setting: Primary care across Greater Manchester, UK.
Article Synopsis
- The text discusses immunobridging, a statistical method used to estimate the vaccine's protective effect in humans based on data from animal studies, specifically in relation to the Ebola vaccine regimen Ad26.ZEBOV and MVA-BN-Filo.
- It presents findings that vaccine-induced antibody levels in humans can remain stable for at least 3.8 years, and immunological memory is retained, evidenced by strong responses to booster vaccinations.
- The discussion highlights the potential benefits for humans in utilizing the anamnestic response to combat Ebola virus, considering their slower disease progression compared to non-human primates, which may allow for effective immune response development.