[Mechanism of the negative action of a bacterial lipopolysaccharide (pyrogenal) on the course of experimental ornithosis infection].

The intravenous injection of pyrogenal into mice following their intravenous infection aggravates the course of ornithosis infection and leads to more intensive multiplication of the infective agent. After the injection of pyrogenal is discontinued a change in the course of the infectious process occurs and the infective agent is quickly eliminated from the body. This is accompanied by increased formation of specific antibodies.

[Effect of leukocyte cation proteins in vitro on the activity of the pathogen of meningopneumonitis].

A study was made of the influence of cation proteins from the lysosomes and nuclei of rabbit polymorphonuclear leukocytes on the survival of the causative agent of meningopneumonia in vitro. As revealed, the greatest antibiotic activity was possessed by the nuclear histones and the low molecular basic proteins of lysosomes. Biological significance of the detected effects is discussed.

[Role of leukocyte disintegration products in increasing macrophage resistance to the causative agent of orinthosis].

The dymanics of formation of macrophagal granulomas in the liver of albino mice was studied after intravenous infection with the causative agent of ornithosis. In formation of granulomas macrophages underwent the stage of reutilization of the leukocyte disintergration and became resistant to the causative agent of ornithosis. Together with the leukocyte remants histones and cation proteins could penetrate into the macrophages cytoplasm; these displayed a high antironithosis activity in vitro.

[Morphological manifestations of secretory activity of the neutrophils in inflammation].

Neutropholic leukocytes of aseptic peritoneal exudate of rabbits differed from neutrophilic leukocytes of the blood in greater variability in the content of cationic proteins. Some lysosomes ceased to be stained on cationic proteins, which produced a false impression of degranulation of leukocytes. Ultramicroscopically, there was observed a "clearing" of the lysosomes content and its outflow into cytoplasm.

[Effect of dilysosomal macrophages on the development and outcome of pneumonia induced by the causative agent of enzootic abortion of sheep].

Repeated intranasal injections of increasing doses of bacterial lipopolysaccharide pyrogenal resulted in accumulation of numerous macrophages in the upper and middle parts of the mouse lungs; these macrophages were filled with leukocyte lysosomes. In these animals dilysosomal macrophages increased local resistance to the agent of enzootic ewe abortion and thus could change the lethal form of induced pneumonia into the nonlethal one.