Publications by authors named "A S Timofeeva"
Article Synopsis
- * It highlights the importance of microglial plasticity and the microenvironment in influencing their polarization pathways, which can lead to either pro-inflammatory or anti-inflammatory responses post-injury.
- * The review provides insights on microglia activation, migration, and their effects on neighboring cells like neurons, astrocytes, and oligodendrocytes, which could help scientists develop better treatment strategies for CNS injuries.
Article Synopsis
- A large-scale study on antibiotic resistance in farm animal feces across Russia analyzed 6,578 samples from 13 regions, with contributions from citizen scientists, especially college students.
- The research utilized microbiological methods to test bacteria's sensitivity to antibiotics and molecular techniques to identify resistance genes, revealing significant regional variations in antibiotic resistance among the samples.
- Findings showed that while some regions had high sensitivity to antibiotics, others exhibited alarming levels of resistance, potentially due to farming practices promoting such resistance.
Article Synopsis
- - Variants in the CTSB gene are linked to an increased risk of Parkinson's disease (PD) and affect the activity of cathepsin B, an enzyme involved in breaking down proteins and regulating cellular processes related to autophagy and lysosome function.
- - CatB can both degrade the harmful alpha-synuclein protein associated with PD and potentially create shorter versions of it that are more prone to aggregation, complicating its role in PD pathology.
- - Experiments showed that inhibiting catB disrupts autophagy and lysosomal function, leading to an accumulation of toxic protein aggregates, while activating catB enhances the clearance of these aggregates in cell and neuron models.
Previous studies have established that rare biallelic SYNJ1 mutations cause autosomal recessive parkinsonism and Parkinson's disease (PD). We analyzed 8165 PD cases, 818 early-onset-PD (EOPD, < 50 years) and 70,363 controls. Burden meta-analysis revealed an association between rare nonsynonymous variants and variants with high Combined Annotation-Dependent Depletion score (> 20) in the Sac1 SYNJ1 domain and PD (Pfdr = 0.
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