[Efficacy and safety of Aviandr in the treatment of anxiety in patients with adjustment disorders after COVID-19].

Objective: To investigate the efficacy and safety of Aviandr in the treatment of anxiety in patients with adjustment disorders after COVID-19.

Material And Methods: A multicenter prospective open-label study included 109 patients of both sexes aged 18 to 65 years (70 women, 39 men, average age - 41.4±13.

Multiscale and multidisciplinary analysis of aging processes in bone.

The world population is increasingly aging, deeply affecting our society by challenging our healthcare systems and presenting an economic burden, thus turning the spotlight on aging-related diseases: exempli gratia, osteoporosis, a silent disease until you suddenly break a bone. The increase in bone fracture risk with age is generally associated with a loss of bone mass and an alteration in the skeletal architecture. However, such changes cannot fully explain increased fragility with age.

[Alveolar rhabdomyosarcoma: novel surrogate markers associated with oncogenic translocation].

Background: Anomalies of the gene in alveolar rhabdomyosarcoma are associated with a worse clinical prognosis, which determines the high value of studying the status of this gene when choosing a therapy strategy. The «gold standard» for determining gene rearrangements is currently the fluorescent in situ hybridization (FISH) technique.

Objective: Study of the relationship between canonical translocation and immunohistochemical expression of new surrogate markers in alveolar rhabdomyosarcoma to determine their predictive value.

Improved inter-residue contact prediction via a hybrid generative model and dynamic loss function.

Protein contact maps represent spatial pairwise inter-residue interactions, providing a protein's translationally and rotationally invariant topological representation. Accurate contact map prediction has been a critical driving force for improving protein structure determination. Contact maps can also be used as a stand-alone tool for varied applications such as prediction of protein-protein interactions, structure-aware thermal stability or physicochemical properties.