V3+ extends the V3 framework to ensure user-centricity and scalability of sensor-based digital health technologies.

We propose the addition of usability validation to the extended V3 framework, now "V3+", and describe a pragmatic approach to ensuring that sensor-based digital health technologies can be used optimally at scale by diverse users. Alongside the original V3 components (verification; analytical validation; clinical validation), usability validation will ensure user-centricity of digital measurement tools, paving the way for more inclusive, reliable, and trustworthy digital measures within clinical research and clinical care.

A Comparative Double-blind Study to Evaluate the Efficacy of Coconut Water and Honey as Cytological Fixatives for Oral Smears.

Introduction: Ninety-five percent ethanol is the routinely used and standard cytological fixative. However, commercially available ethanol is expensive and not freely available in some institutions. There is always a search for an ideal alternative.

Merkel cell: Friend or felon.

Merkel cells are perceived as tactile receptors within skin and oral mucosa containing abundant intermediate filaments but lacking characteristic condensation of tonofilaments, hence are also referred to as non-keratinocytes. Merkel cell carcinomas (MCCs) are primary aggressive neuroendocrine neoplasms occurring in elderly individuals. Toker in 1972 reported MCC of skin pointing towards sweat glands as the source of origin which was later rectified by Tang with the aid of ultrastructural studies as Merkel cells to be a lineage of such tumours.

Beyond Decay: Exploring the Age-associated Variations in and in Dental Caries.

Background: and play an important role in the etiopathogenesis and progression of dental caries (DC). Their quantification and identification may be helpful for epidemiological and early intervention measures.

Objectives: We conducted the study to evaluate the colony counts of and with the location of DC and correlate their prevalence with the age of the patient.

Evaluation of the Impact of Smoking on Orthodontic Treatment.

Smoking is a prevalent habit known for its detrimental effects on oral health and it affects not only oral health but also various organ systems. The influence of smoking on periodontal health, including gingival inflammation, bone loss and delayed wound healing, poses significant challenges during orthodontic therapy. Orthodontic treatment depends on healthy bone and periodontal remodelling.