Psychobiotics improve propionic acid-induced neuroinflammation in juvenile rats, rodent model of autism.

This study aimed to evaluate the protective and therapeutic potency of bee pollen and probiotic mixture on brain intoxication caused by propionic acid (PPA) in juvenile rats. Five groups of six animals each, were used: the control group only receiving phosphate-buffered saline; the bee pollen and probiotic-treated group receiving a combination of an equal quantity of bee pollen and probiotic (0.2 kg/kg body weight); the PPA group being treated for 3 days with an oral neurotoxic dose of PPA (0.

Testing the combined effects of probiotics and prebiotics against neurotoxic effects of propionic acid orally administered to rat pups.

The present study investigated the combined effects of mixed probiotic and bee pollen on brain intoxication induced by propionic acid (PPA) in rat pups. Thirty western albino rats were divided into five groups, six animals each: (1) Control group receiving phosphate-buffered saline; (2) Probiotic and bee pollen-treated group being administered at the same dose with 200 mg/kg body weight; (c) PPA-treated group receiving a neurotoxic dose 250 mg/kg body weight of PPA for 3 days; (d) Therapeutic group being administered the neurotoxic dose of PPA followed by probiotic and bee pollen treatment 200 mg/kg body weight; (e) Protective group receiving probiotic and bee pollen mixture treatment followed by neurotoxic dose of PPA. Selected biochemical parameters linked to oxidative stress, energy metabolism, and neurotransmission were investigated in brain homogenates from all the five groups.

Evaluation and Comparison of Mechanical Properties of Polymer-Modified Asphalt Mixtures.

Polymer modification is extensively used in the Kingdom of Saudi Arabia (KSA) because the available asphalt cement does not satisfy the high-temperature requirements. It was widely used in KSA for more than two decades, and there is little information regarding the differences in the performance of different polymers approved for binder modification. Pavement engineers require performance comparisons among various polymers to select the best polymer for modification rather than make their selection based on satisfying binder specifications.

Kinetics of myxoid liposarcoma radiation response and effects on radiation dose delivery.

Purpose: Recent reports have described the radioresponsiveness of myxoid liposarcomas (MLS). We sought to describe the kinetics of these changes during image guided radiation therapy and determine the effect of these changes in volume on the dose distribution.

Methods And Materials: We reviewed the images of all patients with the diagnosis of MLS who had undergone preoperative radiation therapy using image guidance at our institution.

The neurology of carbonic anhydrase type II deficiency syndrome.

Carbonic anhydrase type II deficiency syndrome is an uncommon autosomal recessive disease with cardinal features including osteopetrosis, renal tubular acidosis and brain calcifications. We describe the neurological, neuro-ophthalmological and neuroradiological features of 23 individuals (10 males, 13 females; ages at final examination 2-29 years) from 10 unrelated consanguineous families with carbonic anhydrase type II deficiency syndrome due to homozygous intron 2 splice site mutation (the 'Arabic mutation'). All patients had osteopetrosis, renal tubular acidosis, developmental delay, short stature and craniofacial disproportion with large cranial vault and broad forehead.