Corticosteroid use to mitigate transaminitis-associated decline in FVIII levels following valoctocogene roxaparvovec gene therapy: clinical practice guidance.

Valoctocogene roxaparvovec is the only factor VIII (FVIII) gene therapy currently approved for adults with severe hemophilia A in Europe and the USA. Elevated alanine transaminase (transaminitis) has been the most common adverse event observed during valoctocogene roxaparvovec clinical trials. Typically mild and transient, this marker of hepatocyte injury coincides, in some patients, with reduced FVIII levels and is generally managed with a reactive course of corticosteroids.

The dilemma of demyelination: A case of Schilder's disease with insights from literature.

We present a case of a young female with Schilder's disease, emphasizing the clinical presentation, diagnostic workup, and management strategies employed.

In vitro anti-inflammatory and in silico anti-viral assessment of phytoconstituents in polyherbal Ayurvedic formulation 'Arogyamrita Kwath'.

Background: Arogyamrita Kwath (AMK) is a polyherbal decoction comprising ten medicinal plants, viz., Albizia lebbeck, Andrographis paniculata, Tinospora cordifolia, Adhatoda vasica, Solanum xanthocarpum, Curcuma longa, Glycyrrhiza glabra, Terminalia bellirica, Withania somnifera and Trachyspermum ammi. The plants of the AMK formulation are traditionally used for the treatment of inflammation and respiratory ailments, but no scientific evidence has been reported so far for this formulation.

To Assess Prevalence of Thyroid Dysfunction in Patients with Heart Failure and Impact on Its Prognosis.

Objective: To evaluate the prevalence of thyroid dysfunction in patients with heart failure (HF) and its impact on prognosis, specifically regarding hospital stay duration.

Methods: One hundred eighty-five HF patients aged >18 years were enrolled, and the study was conducted at Swaroop Rani Nehru Hospital between 21 July 2021, and 20 July 2022. All patients diagnosed with HF underwent demographic, clinical, hematological, biochemical, and thyroid function test (TFT) evaluations.

Efficacy and safety of carbon dioxide versus room-air insufflation in pediatric colonoscopy: a randomized controlled trial.

Background: Adequately powered studies in children are scarce and there are reports on the risk of carbon dioxide (CO2) retention after colonoscopy.

Purpose: This study investigated the efficacy and safety of CO2 insufflation in children undergoing colonoscopy.

Methods: This prospective randomized clinical trial was conducted at a tertiary care hospital between March 2023 and July 2024.