Comparability of the level and intensity of estrogen receptors beta (ERbeta) expression in non-small cell lung cancer tissue of 32 patients was analyzed by flow cytometry using various antibodies--to the total fraction of ERbeta (clone 14C8) as well to the full-length ERbeta1 isoform (clone EMRO2). The differences in the ER expression indexes detected by anti-ERbeta or anti-ERbeta1 antibodies were revealed in some patients, but it had no influence on average indexes of the ERbeta expression in the patient groups investigated. It was confirmed by the findings on more frequent and more intensive expression of ERbeta in the non-small cell lung cancer tissue of female patients vs.
View Article and Find Full Text PDFMolecular markers based on retrotransposon insertions are widely used for various applications including phylogenetic analysis. Multiple cases were described where retrotransposon-based markers, namely sequence-specific amplification polymorphism (SSAP), were superior to other marker types in resolving the phylogenetic relationships due to their higher variability and informativeness. However, the patterns of evolutionary relationships revealed by SSAP may be dependent on the underlying retrotransposon activity in different periods of time.
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