Synthesis of a New Family of 1,1-Diazidoethenes: One-Pot Construction of 4-Azido-1,2,3-triazoles via Nitrene Cyclization.

The reaction of 4,4-dichloro-1,2-diazabuta-1,3-dienes with sodium azide has been studied and found to provide straightforward access to extremely rare 1,1-bisazides. It was demonstrated that these highly unstable compounds are prone to eliminate the N molecule to cyclize into 4-azido-1,2,3-triazoles bearing two aryl (heteroaryl) groups at positions 2 and 5. The formation of bisazides was confirmed by their trapping with cyclooctyne and B3LYP calculations.

[On risk management for occupational diseases, exemplified by major industrial holding].

Analysis of longstanding occupational morbidity helped to determine enterprises forming occupational morbidity in Sverdlovsk region and occupations with most frequently registered these diseases among the workers. In the priority occupations of the enterprises, medial and prophylactic measures are designed and implemented to prevent occupational and occupationally conditioned diseases, from medical examinations to rehabilitation in sanatoriums of the enterprises, with consideration of all financial sources.

A new approach to ferrocene derived alkenes via copper-catalyzed olefination.

A new approach to ferrocenyl haloalkenes and bis-alkenes was elaborated. The key procedure involves copper catalyzed olefination of N-unsubstituted hydrazones, obtained from ferrocene-containing carbonyl compounds and hydrazine, with polyhaloalkanes. The procedure is simple, cheap and could be applied for the utilization of environmentally harmful polyhalocarbons.

Design and synthesis of a new family of fluorinated liquid crystals.

A convenient and simple three-step pathway to the new family of CF(2)CF(2)S-bridged alkanes and CF(2)S-, CF(2)O-bridged alkenes and alkynes was elaborated by using catalytic olefination reaction as a key step of the synthetic sequence. The obtained compounds revealed attractive liquid crystalline characteristics.