Publications by authors named "A S Segura"
Background: Studies have shown associations between polygenic risk scores for educational attainment (PRS), cognitive reserve (CR), cognition, negative symptoms (NS), and psychosocial functioning in first-episode psychosis (FEP). However, their specific interactions remain unclear. This study aimed to investigate the mediating roles of CR, cognition, and NS in the relationship between PRS and psychosocial functioning one year after a FEP.
View Article and Find Full Text PDFPsychopathological manifestations and cognitive impairments are core features of psychotic disorders. Polygenic risk scores (PRS) offer insights into the relationships between genetic vulnerability, symptomatology, and cognitive impairments. This study used a network analysis to explore the connections between PRS, cognition, psychopathology, and overall functional outcomes in individuals experiencing a first episode of psychosis (FEP).
View Article and Find Full Text PDFRecent research suggests that a polygeneric immunogen made from the venoms of the most medically important viperid and elapid snakes in sub-Saharan Africa could elicit a broader antibody response in horses compared to the current EchiTAb-plus-ICP antivenom, especially against neurotoxic elapid venoms. To test this, 25 horses that have been regularly immunized to produce this antivenom were reimmunized with an immunogen containing 22 venoms from various snake species from the genera , , , and both spitting and non-spitting . The plasma collected from these horses was processed using the caprylic acid method to produce an industrial-scale freeze-dried antivenom.
View Article and Find Full Text PDFDisentangling the determinants of trophic structure is central to ecology. The capacity to capture subjugate and consume a prey (i.e.
View Article and Find Full Text PDFArticle Synopsis
- The use of veno-arterial (VA) ECMO is an important technique for supporting patients with severe respiratory and cardiovascular issues, especially as a bridge to recovery or transplant.
- A 77-year-old man with a history of lung transplant faced acute respiratory failure and shock due to CMV pneumonia and required VA ECMO for treatment, receiving significant fluid resuscitation and antibiotics.
- The case demonstrates the complexities of managing fluid resuscitation in lung transplant patients, highlighting that with proper patient selection and a collaborative medical team, successful outcomes can be achieved.