[Semaglutide - effectiveness in weight loss and side effects when used according to studies by SUSTAIN, PIONEER, STEP].

Overweight and obesity are a worldwide common problem and are diagnosed with a body mass index (BMI) value in the range of 25.0-29.9 kg/m2 and ≥30.

[Evaluation of the dynamics of detection of viable SARS-CoV-2 (Coronaviridae: ) in biological samples obtained from patients with COVID-19 in a health care setting, as one of the indicators of the infectivity of the virus].

Introduction: The study of the mechanisms of transmission of the SARS-CoV-2 virus is the basis for building a strategy for anti-epidemic measures in the context of the COVID-19 pandemic. Understanding in what time frame a patient can spread SARS-CoV-2 is just as important as knowing the transmission mechanisms themselves. This information is necessary to develop effective measures to prevent infection by breaking the chains of transmission of the virus.

Changes in the functional activity of mitochondria isolated from the liver of rat that passed the preadaptation to ultra-low deuterium concentration.

The incubation in deuterium-depleted medium of mitochondria isolated from the liver of rats that consumed drinking diet with depleted deuterium (46 ppm) revealed a higher (by 35%) generation of hydrogen peroxide in comparison with the mitochondria (isolated from the liver of rats that consumed drinking diet with 152 ppm deuterium) incubated in medium that contained 152 ppm deuterium. Succinate addition to the reaction system led to an increase in the production of hydrogen peroxide in isolated mitochondria by 44-81%, whereas the difference in the generation of HO between the organelles incubated in mediums 46 and 152 ppm was reduced by 14%. The revealed change in the functional activity of mitochondria suggests the ability of the organism to adapt to the deuterium-depleted drinking diet, which is probably due to the formation of the D/H isotope transmembrane gradient.

[Effect of water isotopic composition on Rhodococcus erythropolis biomass production].

The effect of water isotopic composition on concentration of oil-oxidizing actinobacteria Rhodococcus erythropolis VKM Ac-2017D cellular biomass is observed during cultivation in liquid nutrient media. The value for the effect was determined by experimental conditions, including consecutive use of hydrophilic and hydrophobic nutritious substrates--saccharose and hexadecane. It is shown, that when Rhodococcus erythropolis VKM Ac-2017D cells, cultivated in media with sucrose and 71 and 98 ppm deuterium content in water were inoculated into the similar in mineral and isotopic composition media with hexadecane, a considerable increase in cellular biomass production is observed if compared to a control sample in which water with 150 ppm deuterium concentration was used.

[Treatment of pathologic hip dislocation caused by hematogenic osteomyelitis in children and adolescents].

The article discusses 94 patients with pathological dislocation of the hip after hematogenous osteomyelitis who underwent reconstructive-restorative operations on 101 joints. According to the clinical and X-ray signs, all patients were divided into 4 main groups. The types of surgical interventions performed depending on the severity of involvement of the proximal part of the femur and the acetabulum are indicated.