Publications by authors named "A S Rosado"
Enhanced UV-B photoprotection activity of carotenoids from the novel sp. strain LAPM80 isolated from King George Island, Antarctica.
Heliyon
January 2025
Antarctica's harsh environmental conditions, characterized by high levels of ultraviolet (UV) radiation, pose challenges for microorganisms. To survive in these extreme cold regions with heightened UV exposure, microorganisms employ various adaptive strategies, including photoprotective carotenoid synthesis. Carotenoids are garnering attention in the skin health industry because of their UV photoprotection potential, given the direct relationship between UV exposure and skin burns, and cancer.
View Article and Find Full Text PDFObjective: Complex ablative maxillary and mandibular defects often require osseous free flap reconstruction. Workhorse options include the fibula, scapula, and osteocutaneous radial forearm flap (OCRFF). The choice of donor site for harvest should be driven not only by reconstructive goals but also by donor site morbidity.
View Article and Find Full Text PDFSome bacteria possess microcompartments that function as protein-based organelles. Bacterial microcompartments (BMCs) sequester enzymes to optimize metabolic reactions. Several BMCs have been characterized to date, including carboxysomes and metabolosomes.
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- - Patients with chronic kidney disease (CKD) have elevated levels of trimethylamine N-oxide (TMAO), a harmful substance linked to heart disease, and the study explores how gut microbes, specifically methanogenic archaea, might help reduce TMAO by consuming its precursor, trimethylamine (TMA).
- - The study involved 25 CKD patients, where TMAO levels were measured and gut microbial DNA was sequenced, revealing high TMAO levels and a connection to archaea, particularly a significant negative correlation with the genus Methanobrevibacter.
- - This research is pioneering in linking TMAO levels with archaea in CKD patients, highlighting the potential role of specific
Inhibition of branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK), a negative regulator of branched-chain amino acid (BCAA) metabolism, is hypothesized to treat cardio-metabolic diseases. From a starting point with potential idiosyncratic toxicity risk, modification to a benzothiophene core and discovery of a cryptic pocket allowed for improved potency with 3-aryl substitution to arrive at PF-07328948, which was largely devoid of protein covalent binding liability. This BDK inhibitor was shown also to be a BDK degrader in cells and in vivo rodent studies.
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