Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation.

Pro-inflammatory macrophage activation is a hallmark example of how mitochondria serve as signaling organelles. Oxidative phosphorylation sharply decreases upon classical macrophage activation, as mitochondria are thought to shift from ATP production towards accumulating signals that amplify effector function. However, evidence is conflicting regarding whether this collapse in respiration is essential or dispensable.

Hybrid and Plant-Based Burgers: Trends, Challenges, and Physicochemical and Sensory Qualities.

Burgers have become a staple of global cuisine and can have several different versions and combinations. For example, hybrid burgers have a percentage of animal protein in their formulation, while plant-based burgers contain 100% plant-based proteins. Therefore, the aim of this study was to investigate the emerging trends and challenges in the formulation of hybrid and plant-based burgers, with an emphasis on new ingredients and the evaluation of their physical, chemical, and sensory properties.

(Dis)connecting the Globe Through Water-Driven Ecological and Biogeochemical Corridors in the Polar-Alpine Biome.

Global change is causing the melting of ice masses, permafrost thawing, and the shrinking of glaciers, thereby reshaping nature's rhythms. Longer thaw phases and more frequent dry periods are transforming water-driven transitional ecosystems (e.g.

Electrical asymmetrical flow field-flow fractionation: Fundamentals, evolution, applications, and prospects.

Among the plethora of techniques that conforms the Field-Flow Fractionation (FFF) family, electrical field-flow fractionation (ElFFF) was designed to separate different analytes based on their size and electrophoretic mobility (µ). However, major technical and operational issues made this technique to fall into oblivion. Many of those drawbacks can be circumvented if another field is employed as the main driving force for the elution in the same channel, such as the most successful and useful FFF-related technique, asymmetrical flow field-flow fractionation (AF4).

Metabolic regulation of RNA methylation by the mA-reader IGF2BP3.

The interplay of RNA modifications - deposited by "writers", removed by "erasers" and identified by RNA binding proteins known as "readers" - forms the basis of the epitranscriptomic gene regulation hypothesis. Recent studies have identified the oncofetal RNA-binding protein IGF2BP3 as a "reader" of the N6-methyladenosine (mA) modification and crucial for regulating gene expression. Yet, how its function as a reader overlaps with its critical oncogenic function in leukemia remains an open question.