The oral drug obeldesivir protects nonhuman primates against lethal Ebola virus infection.

Obeldesivir (ODV; GS-5245) is an orally administered ester prodrug of the parent nucleoside GS-441524 that has broad spectrum antiviral activity inhibiting viral RNA-dependent RNA polymerases. We recently showed that ODV completely protects cynomolgus macaques against lethal infection with Sudan virus when given 24 hours after parenteral exposure. Here, we report that once daily oral ODV treatment of cynomolgus and rhesus macaques for 10 days confers 80 and 100% protection, respectively, against lethal Ebola virus infection when treatment is initiated 24 hours after mucosal (conjunctival) exposure.

Vacancy Ordered Double Perovskites [N(CH3)4]2SnX6 (X = Cl, Br, I): Thermal Phase Transition and Wide Range Optical Absorption.

TMA)2SnX6 (TMA = tetramethylammonium; X = Cl, Br, I) compounds form vacancy-ordered halide double perovskites (VODPs) with TMA+ cation in the A-site, Sn4+ cation in the M-site and X- anion in the halide site. This study reports the synthesis and structural phase transition of (TMA)₂SnCl₆, (TMA)2SnCl0.7Br5.