Pharmacokinetics of Two Nanoemulsion Formulations of Δ-Tetrahydrocannabinol in Rats.

The use of Δ-tetrahydrocannabinol (Δ-THC) has increased in recent years. Given that the oral absorption of cannabinoids in oil formulations is typically slow and variable, nanoemulsions may be an improved delivery vehicle. Therefore, we characterized the pharmacokinetics (PK) in Sprague-Dawley rats following the administration of three different oral formulations containing 10 mg/kg Δ-THC: a translucent liquid nanoemulsion, a reconstituted powder nanoemulsion, and a medium chain triglyceride (MCT) oil solution for comparison.

Noise-resilient multi-frequency surface sensor for nuclear quadrupole resonance.

A planar nuclear quadrupole resonance (NQR) sensor has been developed. The sensor is resilient to environmental noise and is capable of simultaneous independent multi-frequency operation. The device was constructed as an open multimodal birdcage structure, in which the higher modes, generally not used in magnetic resonance, are utilized for NQR detection.

Shock-wave model of acoustic cavitation.

Shock-wave model of liquid cavitation due to an acoustic wave was developed, showing how the primary energy of an acoustic radiator is absorbed in the cavitation region owing to the formation of spherical shock-waves inside each gas bubble. The model is based on the concept of a hypothetical spatial wave moving through the cavitation region. It permits using the classical system of Rankine-Hugoniot equations to calculate the total energy absorbed in the cavitation region.

SENSE imaging with a quadrature half-volume transverse electromagnetic (TEM) coil at 4T.

Purpose: To demonstrate the feasibility of high-field SENSE imaging of large objects, such as the human head, using a semicircular (half-volume) coil for both transmission and multi-channel reception.

Materials And Methods: As a proof of concept, we present experimental data obtained using a seven-element half-volume (180 degrees of arc) transmit/receive quadrature transverse electromagnetic (TEM) coil. SENSE images of the human brain were acquired with a reduction factor of R=2, using two degenerate linear modes of the same coil as independent receive channels at 4T.

Matching a transducer to water at cavitation: acoustic horn design principles.

High-power ultrasound for several decades has been an integral part of many industrial processes conducted in aqueous solutions. Maximizing the transfer efficiency of the acoustic energy between electromechanical transducers and water at cavitation is crucial when designing industrial ultrasonic reactors with large active volumes. This can be achieved by matching the acoustic impedances of transducers to water at cavitation using appropriately designed ultrasonic horns.