Patient-Directed Discharge in Hand Infection Cases: Interactions Between Intravenous Drug Use, Socioeconomic Factors, and Subsequent Readmissions.

Background: Patient-directed discharge (PDD) poses a significant challenge in healthcare. Prior studies have shown associations of PDD with factors like race, housing, psychiatric illness, socioeconomic status, and intravenous drug use (IVDU). This study aims to identify factors contributing to PDD in hand infection patients at a public safety-net hospital and to investigate the long-term consequences through readmissions or returns to the emergency department (ED).

The role of F-fluorodeoxyglucose positron emission tomography/computed tomography-derived parameters as prognostic factors in patients undergoing resection for pancreatic ductal adenocarcinoma.

Background: The aim of this study is to investigate the role of maximum standardized uptake and tumor-to-liver ratio derived from preoperative F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with pancreatic ductal adenocarcinoma.

Methods: Patients who underwent pancreatic resection from January 2015 to December 2022 were reviewed. Patients were grouped based on disease-free survival of 1 year, disease-free survival of 6 months, overall survival of 1 year, and resectability.

The Natural History of Pediatric Cerebellopontine Angle Lipomas.

Objective: To present a series of pediatric patients with cerebellopontine angle (CPA) lipomas in order to understand their natural history and facilitate management recommendations.

Patients: Pediatric patients with a diagnosis of CPA lipoma.

Interventions: Clinical data collected from a single tertiary care center between January 2000 and August 2022.

Bioprospecting of cellulases from marine fungi for macro-algal biomass degradation for biofuel application.

The marine ecosystem, the largest on Earth, supports around 80 % of plant and animal species. Marine macroalgae, rich in polysaccharides like cellulose, remain underutilized despite their potential in a circular bioeconomy. Efficient valorization can promote sustainability, whereas mismanagement raises ecological concerns.

Gold nanoparticles-based targeted delivery of rapamycin and Olaparib to breast cancer: An in vitro and in vivo approach.

Triple negative form of breast cancer (abbreviated as TNBC) is considered as the most aggressive form causing high mortality worldwide. Different treatment modalities such as chemotherapy, surgery, hormonal therapy and radiation therapy are employed for eliminating breast cancer, which are associated with many limitations. Therefore, considering the significance of metal nanoparticles in the biomedical sector, especially gold nanoparticles, in the current manuscript, we have designed and developed a combinatorial approach for synthesizing two types of gold (Au) nanoformulations (Au-Dex-MUA-Rapa, Au-Dex-MUA-Ola) using 11-mercaptoundecanoic acid (MUA), dexamethasone (Dex) (glucocorticoid receptor targeted molecule) along with rapamycin (Rapa: inhibitor of mTOR) or olaparib (Ola: inhibitor of PARP) against TNBC.