Publications by authors named "A S Pages"
Objectives: To investigate the safety and efficacy outcomes of intravenous thrombolysis (IVT) in patients aged >80 years with acute ischaemic stroke (AIS) after IVT was approved in this patient population in several European and non-European countries during 2018-2019.
Design: This is an observational registry study using prospectively collected data from the Safe Implementation of Treatment in Stroke (SITS) registry. Comparisons will be performed between patients treated post-approval (July 2018 to December 2021) period with those treated pre-approval (June 2015 to June 2018) period using propensity score matching (PSM).
Introduction: In the past, certain oncological therapies were not offered to frail older patients. However, the advancement of geriatric oncology, tailored chemotherapy regimens, the introduction of new treatments, and the optimization of supportive care have contributed to enhancing the therapeutic margin. We aimed to evaluate the benefit of systemic treatment among older adults by assessing the three-month survival of older frail patients with metastatic cancer.
View Article and Find Full Text PDFChronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy with limited therapeutic options. Single-cell analysis of clonal architecture demonstrates early clonal dominance with few residual WT hematopoietic stem cells. Circulating myeloid cells of the leukemic clone and the cytokines they produce generate a deleterious inflammatory climate.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the use of alteplase thrombolysis in patients with severe hypoxemic respiratory failure caused by COVID-19, comparing it to standard care (SOC) alone.
- Results showed that patients receiving alteplase experienced a median time to clinical improvement of 25 days compared to more than 28 days for those on SOC, along with a lower mortality rate (12% vs. 29%).
- However, 26.1% of the alteplase group had to stop treatment due to adverse effects, and major bleeding incidents were more common in the alteplase group, although no fatalities occurred.