Publications by authors named "A S Montaser"
This study focused on the potential of Gliricidia sepium (Jacq.) Kunth. ex.
View Article and Find Full Text PDFl-type amino acid transporter 1 (LAT1) is a membrane transporter responsible for carrying large, neutral l-configured amino acids as well as appropriate (pro)drugs into a cell. It has shown a great potential to improve drug delivery across the blood-brain barrier and to increase cell uptake into several brain and cancer cell types. However, besides the brain, the LAT1-utilizing compounds are also delivered more efficiently into the pancreas in vivo.
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- Inherited retinal degenerations (IRDs) are a leading cause of blindness in young people, often starting with night vision loss and visual field decline, primarily seen in retinitis pigmentosa (RP).
- The study used different mouse models representing various types of RP and Leber’s congenital amaurosis to analyze retinal proteins, employing consistent methods across institutions for reliable results.
- Findings revealed common issues like inflammation and cellular stress across models, yet distinct pathologies, particularly distinguishing between RP types, while highlighting cAMP and cGMP signaling pathways as potential targets for future therapies.
The accumulation of uremic toxins in the human body poses a deadly risk because it causes chronic kidney disease. To increase the effectiveness of hemodialysis and raise the survival rate, these toxins must be effectively removed from the bloodstream. Developing effective materials for removing these dangerous substances requires a thorough understanding of the interactions between an adsorbent and the uremic toxins.
View Article and Find Full Text PDFObjective: Cerebral revascularization surgery (CRS) has been used to prevent stroke in children with sickle cell disease (SCD) and cerebral vasculopathy (e.g., moyamoya syndrome).
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