Publications by authors named "A S Milton"
Differential Cytotoxic Effects of Cell-Free Supernatants of Emerging Pathogens and on Four Cell Lines Reveal Vero Cells as a Putative Candidate for Cytotoxicity Analysis.
Microorganisms
November 2024
and are recognized as emerging pathogens with zoonotic potential. Despite their increasing importance, there is a paucity of data on the cytotoxicity of these two pathogens. Therefore, in the present study, we investigated the cytotoxic potentials of the cell-free supernatants from 10 and 15 isolates for their cytotoxic effects on four different cell lines (CHO, Vero, HeLa, and MDCK).
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- The Western Ghat region of Kerala has rich biodiversity that supports tick populations, which carry the Kyasanur Forest Disease virus (KFDV), known to cause hemorrhagic fever or "monkey fever."
- Tick infestations are common in local livestock, as these animals often graze in nearby forests, leading to increased risk of farmers contracting tick-borne diseases.
- While KFDV is widespread, data on other related viruses like CCHFV and GANV is limited, though a small percentage of livestock showed CCHFV exposure, indicating the need for further research and surveillance to identify disease hotspots.
Segmentation of breast lesion using fuzzy thresholding and deep learning.
Comput Biol Med
January 2025
Breast cancer is a major cause of morbidity and mortality in women. In breast cancer screening, Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) has shown promise as a technique, providing enhanced temporal patterns of breast tissues. This study proposes an enhanced segmentation method for identifying breast lesions.
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- This study focuses on the genomics of zoonotic foodborne pathogens originating from pigs, highlighting the limited knowledge in this area.
- Researchers analyzed pig-derived genomes alongside existing data to explore their genetic features, virulence, resistance, and phylogenomic relationships.
- Findings show that most pig isolates belong to a specific clonal complex, with a significant presence of antibiotic resistance genes and a diverse set of mobile genetic elements, indicating potential public health implications.
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- Digital health interventions (DHIs) could offer low-cost, scalable improvements in care for adults with schizophrenia, with a review assessing their efficacy through randomized controlled trials (RCTs) that incorporate human support.
- A systematic search identified 26 RCTs involving 2,481 participants, finding no significant improvements in psychosis symptoms or overall health outcomes, though there was a notable trend towards benefits in social cognition and quality of life.
- The study concludes that while DHIs are feasible and may improve health outcomes with human support, more high-quality research is needed to explore their long-term effectiveness and integration of technology in clinical practice.