An institution-wide mixed methods assessment of healthcare transition.

Background: Healthcare transition (HCT) is the process of moving a patient from pediatric, parent-supervised care to an independent, adult-centered model. This study assesses current HCT activities and explores the educational and system-based needs for effective HCT processes in a single institution.

Methods: We interviewed division/care program leaders at one academic tertiary-care children's hospital regarding HCT practices.

From algae to plants: understanding pyrenoid-based CO-concentrating mechanisms.

Pyrenoids are the key component of one of the most abundant biological CO concentration mechanisms found in nature. Pyrenoid-based CO-concentrating mechanisms (pCCMs) are estimated to account for one third of global photosynthetic CO capture. Our molecular understanding of how pyrenoids work is based largely on work in the green algae Chlamydomonas reinhardtii.

Discordance Between Caregiver and Transplant Clinician Priorities Regarding Post-Heart Transplant Education.

Background: Patient and caregiver education following pediatric heart transplant (HTx) is a cornerstone of post-HTx care. Despite the importance of post-HTx education, there are no standardized guidelines for topics and content. Education practices vary across clinicians and centers.

SAGA1 and MITH1 produce matrix-traversing membranes in the CO-fixing pyrenoid.

Approximately one-third of global CO assimilation is performed by the pyrenoid, a liquid-like organelle found in most algae and some plants. Specialized pyrenoid-traversing membranes are hypothesized to drive CO assimilation in the pyrenoid by delivering concentrated CO, but how these membranes are made to traverse the pyrenoid matrix remains unknown. Here we show that proteins SAGA1 and MITH1 cause membranes to traverse the pyrenoid matrix in the model alga Chlamydomonas reinhardtii.