Computational biology assisted exploration of phytochemicals derived natural inhibitors to block BZLF1 gene activation of Epstein-Bar virus in host.

The Epstein-Barr virus (EBV) is widespread and has been related to a variety of malignancies as well as infectious mononucleosis. Despite the lack of a vaccination, antiviral medications offer some therapy alternatives. The EBV BZLF1 gene significantly impacts viral replication and infection severity.

Strength, durability, and economic analysis of GGBS-based geopolymer concrete with silica fume under harsh conditions.

Geopolymer concrete (GPC) offers a sustainable alternative by eliminating the need for cement, thereby reducing carbon dioxide emissions. Using durable concrete helps prevent the corrosion of reinforcing bars and reduces spalling caused by chemical attacks. This study investigates the impact of adding 5, 10, and 15% silica fumes (SF) on the mechanical and durability properties of GPC cured at 60 °C for 24 h.

The Advancement of Peptides Derived from Kitasatospora.

Kitasatospora continue to be a rich source of chemically diverse and bioactive peptide natural products. This review highlights two strategies in peptide natural products research of Kitasatospora, 1) natural product-first approach guided by a major compound, biological activity or genomic analysis, and 2) enzyme-first approach guided by bioinformatic tools to construct a sequence similarity network for the discovery of biosynthetic enzymes. The structures of peptides, biosynthetic origins of unique building blocks, recent reports of post-translational modifying enzymes for constructing these peptides, and knowledge gap in biosynthesis will also be presented.

Gone with the Species: From Gene Loss to Gene Extinction.

Background: Vertebrae protein-coding genes exhibit remarkable diversity and are organized into many gene families. These gene families have emerged through various gene duplication events, the most prominent being the two rounds of whole-genome duplication (WGD). The current research project analyzed a unique class of genes called "singletons".