Vaccine hesitancy among Syrian refugee parents in Canada: A multifaceted challenge in public health.

Vaccine hesitancy presents a significant public health challenge, particularly among Syrian refugee parents in Canada, who navigate unique barriers to vaccination. This cross-sectional study explores the determinants of vaccine hesitancy, considering socio-demographic factors, resettlement conditions, health assessments, and healthcare system interactions. The study involved 540 Syrian refugee parents residing in Ontario with at least one child under 18, interviewed from March 2021 to March 2022.

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations and .

Aberrant activation of Wnt signaling results in unregulated accumulation of cytosolic β-catenin, which subsequently enters the nucleus and promotes transcription of genes that contribute to cellular proliferation and malignancy. Here, we sought to eliminate pathogenic β-catenin from the cytosol using designer ubiquibodies (uAbs), chimeric proteins composed of an E3 ubiquitin ligase and a target-binding domain that redirect intracellular proteins to the proteasome for degradation. To accelerate uAb development, we leveraged a protein language model (pLM)-driven algorithm called SaLT&PepPr to computationally design "guide" peptides with affinity for β-catenin, which were subsequently fused to the catalytic domain of a human E3 called C-terminus of Hsp70-interacting protein (CHIP).

Resilience Mechanisms and Coping Strategies for Forcibly Displaced Youth: An Exploratory Rapid Review.

The global escalation of conflict, violence, and human rights violations sets a pressing backdrop for examining the resilience of forcibly displaced youth (FDY) in Canada. This study aims to unpack the multifaceted challenges and resilience mechanisms of FDY, focusing on their health, well-being, and integration into host communities. It seeks to identify current models of resilience, understand the factors within each model, and highlight gaps and limitations.

Gender, sexuality and cis-heteropatriarchal parental control: navigating the politics of neo-panopticon and the resilience of young Khawaja Sara and Hijra in Peshawar, Pakistan.

Background: Scholarly works have extensively explored the marginalized positions of transgender individuals in Pakistan. However, there is a noticeable gap in literature concerning the profound impact of cis-heteropatriarchal parental control on young Khawaja Sara and Hijra individuals-members of the transgender community-particularly when they reside in their parental homes in Peshawar, Pakistan.

Aim: Grounded in Foucault's panopticon concept, this study seeks to illuminate the pervasive surveillance experienced by young Khawaja Sara and Hijra within the confines of their familial environments.