Publications by authors named "A S Leroyer"
Article Synopsis
- The incidence of inflammatory bowel disease (IBD) in Northern France was studied over a 30-year period, revealing 22,879 new cases, with Crohn's disease (CD) and ulcerative colitis (UC) making up the majority.
- The incidence rates for both CD and UC increased significantly over the years, particularly in children and young adults, indicating a rising trend in these demographics.
- The findings suggest ongoing environmental factors contributing to the increasing prevalence of IBD, especially among women with UC, with projections indicating that nearly 0.6% of the population will have IBD by 2030.
Tumor development necessitates immune escape through different mechanisms. To counteract these effects, the development of therapies targeting Immune Checkpoints (ICP) has generated interest as they have produced lasting objective responses in patients with advanced metastatic tumors. However, many tumors do not respond to inhibitors of ICP, necessitating to further study the underlying mechanisms of exhaustion.
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- Patients with inflammatory bowel disease (IBD), specifically children with Crohn's disease (CD) and ulcerative colitis (UC), have a higher risk of thromboembolic events (TE), but more information is needed regarding the incidence and risk factors for better preventative care.
- The study followed 1,344 pediatric patients from 1988 to 2013, finding very few instances of arterial (ATE) and venous thromboembolic events (VTE) during the follow-up period, with VTE being more frequent in specific circumstances.
- Overall, while the risk of TE in this population is low, it was significantly linked to periods of active disease, post-surgery conditions, and hospitalization, while treatment with
Article Synopsis
- Immune thrombotic thrombocytopenic purpura (i-TTP) is a serious condition characterized by a deficiency in ADAMTS-13 and is thought to start with the activation of endothelial cells, leading to vascular damage.
- The study aimed to explore how endothelial cells detach during thrombotic thrombocytopenic purpura by examining circulating endothelial cells (CECs) in patients and their relationship to disease severity and calcium signaling.
- Results showed that plasma from i-TTP patients led to greater detachment and altered behavior of endothelial cells compared to control plasma, suggesting that increased vascular permeability may be a key factor in the pathogenesis of the disease.