Impact of Cardiorespiratory Fitness on COVID-19-Related Outcomes: The Exercise Testing and Health Outcomes Study (ETHOS).

Objective: To assess the association between cardiorespiratory fitness (CRF) and COVID-19-related health outcomes including mortality, hospitalization, and mechanical ventilation.

Patients And Methods: In a retrospective analysis of 750,302 patients included in the Exercise Testing and Health Outcomes Study, we identified 23,140 who had a positive result on COVID-19 testing between March 2020 and September 2021 and underwent a maximal exercise test in the Veterans Affairs Health Care System between October 1, 1999 to September 3, 2020. The association between CRF and risk for severe COVID-19 outcomes, including mortality, hospitalization due to COVID-19, and need for intubation was assessed after adjustment for 15 covariates.

Towards a hybrid approach to unveil the Chimaira of neurosciences: philosophy, aperiodic activity and the neural correlates of consciousness.

Contemporary theories of consciousness, although very efficient in postulating testable hypotheses, seem to either neglect its relational aspect or to have a profound difficulty in operationalizing this aspect in a measurable manner. We further argue that the analysis of periodic brain activity is inadequate to reveal consciousness's subjective facet. This creates an important epistemic gap in the quest for the neural correlates of consciousness.

Prospective Memory, Sustained Attention and Response Inhibition in Poly-Substance Users Stable on Methadone Maintenance Treatment.

: Prospective memory and response inhibition are interrelated constructs, though studied separately in the drug addiction literature. Also, although sustained attention underlies response inhibition, its role in the relation between these functions has been largely neglected. The limited research on the cognitive effects of methadone-maintenance treatment (MMT) further stresses the importance of investigating these effects.

Arterial Stiffness Alterations in Simulated Microgravity and Reactive Sledge as a Countermeasure.

Introduction: Experiments during spaceflight and simulated microgravity as head-down tilt bedrest, demonstrated the role of arterial stiffness among others, in microgravity induced cardiovascular pathologies and emphasized the need for a robust countermeasure.

Aim: The purpose of the present study was to evaluate the use of a new countermeasure, consisting of a high intensity Reactive Sledge (RSL) jumps training protocol, to counteract changes in arterial stiffness during long term head down tilt bedrest (LTBR).

Methods: The participants enrolled in the study were 23 male, healthy volunteers, aged between 20 and 45 years, subjected to LTBR for 60 days and randomly assigned either to a control (11) or to a training sledge (12) group using RSL 3-4 times per week, as a countermeasure.