[Activity of the NO-system in lung after pulmonectomy of various volumes].

The study was designed to evaluate the activity of NO-system in lung after resection of various volumes. White male rats, subjected to left or right pulmonectomy, were used. Activity of the NO-system in lung was estimated as a difference in the contents of its metabolites (nitrates NO3(-) and nitrites NO2(-)), peroxynitrite (ONOO(-)), activity of endothelial (eNOS) and induced enzyme (iNOS), in arterial and venous blood for 3, 7, 14 day after pulmonectomy.

[Experimental and clinical evaluation of the efficacy of ecdysten in the treatment of hepatitis].

The properties of ecdysten, an exdysterone-based preparation, were studied under experimental (of heliotrine induced hepatitis model in rats) and clinical (chronic viral hepatitis B) conditions. A 2-week treatment with ecdysten in a daily dose of 5 mg/kg (p.o.

[The state of lipid peroxidation and of the antioxidant system in the liver and lung microsomes at different periods of sensitization depending on the histamine content].

Histamine impact on lipid peroxidation (LPO) in hepatic and pulmonary microsomes of guinea-pigs sensibilization was studied. It is demonstrated that intensity of chemiluminescence and LPO product content in NADPH-, ascorbat-dependent and spontaneous systems was enhanced in relation to the period of sensibilization process formation and histamine concentration.

[The detoxifying function of the liver in acute experimental intestinal obstruction].

The detoxifying function of the liver was studied in experiments on male rats with acute obstructive and strangulation ileus. Irrespective of its type, acute ileus was attended by marked diminution of hepatic detoxifying function the underlying factor of which was inhibited activity of the main microsomal enzymes and reduced content of cytochromes p50 and b5 in the liver. Intoxication of the organism and hypoxia developing in the liver were among the causes of inhibited activity of the microsomal enzymes.