Publications by authors named "A S Kolios"
Article Synopsis
- * Current guidelines advise TB screening and preventive treatment prior to starting anti-TNF therapy, extending to other biologic therapies despite differing mechanisms of action.
- * New evidence suggests that some emerging therapies might not significantly raise TB reactivation risk, prompting calls to revise existing recommendations to better reflect individual patient risks and drug safety.
Article Synopsis
- - Dupilumab shows promise as a treatment for bullous pemphigoid (BP), allowing for the rapid identification of patients who respond to the therapy, which could reduce the need for additional immunosuppressive treatments.
- - In a study of 12 BP patients, 67% had a complete response and a significant reduction in itch (pruritus) was noted as early as day 1, with a correlation to clinical improvement by day 14.
- - The findings suggest that monitoring itch levels can be a useful early indicator of treatment response, potentially altering BP treatment protocols in the future to minimize reliance on more harmful therapies.
Article Synopsis
- Pityriasis rubra pilaris (PRP) is a rare skin condition with unclear causes, but recent research identified IL-1β as a crucial factor in its development.
- Treatment with IL-1 antagonists like anakinra and canakinumab led to significant improvements in patients, including reduced skin lesions within a few weeks.
- The findings suggest that PRP could be redefined as an autoinflammatory keratinization disorder, highlighting the need for further clinical trials to test the effectiveness of targeting IL-1β in treatment.