[Features of binding of proflavine to DNA at different DNA-ligand concentration ratios].

The binding of proflavine to calf thymus DNA has been studied using the methods of differential scanning calorimetry and spectrophotometry. It was shown that proflavine can interact with DNA by at least 3 binding modes. At high DNA-ligand concentration ratios (P/D), proflavine intercalates into both GC- and AT-sites, with a preference to GC-rich sequences.

[Interaction of actinocin derivative with different poly(rC) structures].

The interaction of actinocin derivative Act III with single- and double-stranded poly(rC) has been investigated by the methods of differential scanning microcalorimetry and UV-vis absorption spectroscopy. It was shown that, after the addition of the ligand, the temperature, enthalpy and entropy of poly (rC) melting decrease. The analysis of poly(rC)-ActIII absorption spectra indicated that the conformation of polynucleotide differs from that of free poly (rC) in the presence of ActHI at pH 4.

[Effect of personality traits on levels of lipid peroxidation products in serum and the blood antioxidant activity].

Psychometris evaluation of personality traits and subsequent laboratory study of lipoperoxidation products in blood serum and its antioxidative activity were performed in 27 healthy volunteers. Data obtained suggest that personality traits determinate to a certain extent the lipoperoxidation and blood serum antioxidative activity.