[Calculation of intraocular lens power in non-standard clinical situations].

Methods of intraocular lens (IOL) calculation in non-standard clinical situations have been developed and introduced. These include a formula that improves the calculation accuracy in patients with relatively short anterior-posterior axis and another method for eyes after previous radial keratotomy. A comparative clinical evaluation of the proposed methods has been performed.

[Preferred distances between DNA binding sites for factors regulating transcription initiation].

Transcriptional regulation of gene expression in higher eukaryotes is driven by sophisticated protein complexes of transcription factors. On the DNA level, there are composite elements containing sites of different DNA-binding proteins. We use the hypoxia-response system to identify preferred localization distances for the 'hypoxia-induced factor-1 binding site-co-factor binding site" pairs in promoter DNA regions of the human genome.

[Intracellular tetanization by the hyperpolarizing current potentiates synapses formed by mossy fibers on the pyramidal cells of the CA3 hyppocampal area of the rat].

Whole-cell recordings of excitatory postsynaptic potentials evoked by the minimum stimulation of mossy fiber inputs were performed in CA3pyramidal neurons in rat hippocampal slices. Paired responses were recorded before and after intracellular hyperpolarization tetanization. This procedure produced an increase in excitatory postsynaptic potentials at least for 20-min recording period.