Publications by authors named "A S J Ting"
Single cell sequencing technologies have revolutionized our understanding of biology by mapping cell diversity and gene expression in healthy and diseased tissues. While single-cell RNA sequencing (scRNA-seq) has been widely used, interest in single-nucleus RNA sequencing (snRNA-seq) is growing due to its benefits, including the ability to analyze archival tissues and capture rare cell types that are challenging to dissociate. However, comparative studies across tissues have yielded mixed results, with some reporting enhanced cell type retention using snRNA-seq while others finding cell type identification to be challenging in snRNA-seq data.
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- Chronic exposure to electronic cigarette (E-cig) vapor, especially with nicotine, did not significantly impact blood pressure or cardiac function in young rats, unlike standard cigarette smoke which raised these measures.
- In older rats, E-cig exposure did not affect heart rate or blood pressure, but nicotine vaping was linked to increased heart and left ventricle weight compared to air exposure.
- Overall, while acute E-cig vapor exposure raises blood pressure, long-term effects appear less harmful compared to traditional cigarette smoke in both young and old rats.