Publications by authors named "A S Hsiao"
Purpose To measure the benefit of single-phase CT, inspiratory-expiratory CT, and clinical data for convolutional neural network (CNN)-based chronic obstructive pulmonary disease (COPD) staging. Materials and Methods This retrospective study included inspiratory and expiratory lung CT images and spirometry measurements acquired between November 2007 and April 2011 from 8893 participants (mean age, 59.6 years ± 9.
View Article and Find Full Text PDFThe HIV epidemic remains a critical public health priority in the United States. The Ending the HIV Epidemic (EHE) initiative seeks to reduce HIV diagnoses by 75% by 2025 and by 90% by 2030. Certain demographic groups-including transgender women, cisgender Black women, and Black/African American and Hispanic/Latino men who have sex with men-are disproportionately affected by HIV.
View Article and Find Full Text PDFArticle Synopsis
- - In 2014, the PCV13 vaccine was recommended for adults 65 and older, aiming to reduce invasive pneumococcal disease (IPD), yet cases of serotype 3 lingered despite overall declines in other serotypes.
- - A study conducted from 2014 to 2020 within Kaiser Permanente Northern California evaluated the effectiveness of PCV13 in preventing IPD in this age group, analyzing over 610,000 participants.
- - The findings showed that the vaccine was 61.5% effective against PCV13-serotype IPD and 46.3% effective against serotype 3, highlighting the need for ongoing monitoring of vaccine impact on IPD across different serotypes. *
Purpose: Circulating tumor DNA (ctDNA) can reflect the genetic and epigenetic composition of malignancies and can serve as a noninvasive biomarker for cancer diagnostics and monitoring. This study aimed to evaluate the utility of a methylation-based ctDNA assay as a predictive tool in non-small cell lung cancer (NSCLC) anti-PD1 based immunotherapy monitoring.
Methods: We evaluated a cohort of 20 patients with NSCLC treated with anti-PD1 based immunotherapy that had both baseline and follow-up blood draws as well as outcome data available.
Article Synopsis
- - PBDEs, used as flame retardants, are harmful pollutants that disrupt endocrine function and alter neurobehavior and metabolism, especially during development.
- - A study tested if maternal probiotic supplementation with Limosilactobacillus reuteri could protect offspring against negative effects caused by PBDE exposure, focusing on gut microbiome diversity and developmental health.
- - Results showed that maternal LR supplementation improved gut microbiome health and developmental outcomes in PBDE-exposed offspring, leading to normalized body weight gain and corrected timing of tooth eruption in both sexes.