New highly efficient phosphorescent manganese halides as green and blue emitters.

Three new manganese compounds on 5-(pyridin-2-yl)-3-phenyl-1,2,4-triazole (L) basis (HL)[MnBr]·HO (1), (HL)[MnCl] (2) and [MnLCl]·HO (3) have been synthesized and characterized in terms of their structure, photoluminescence (PL), and electroluminescence (EL) properties. Compounds 1 and 2 exhibit bright green luminescence ( ≈ 550 nm) with high quantum yields of 75.1 and 71.

A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide.

N-Acetylgalactosamine (GalNAc) is an efficient and multifunctional delivery tool in the development and synthesis of chemically modified oligonucleotide therapeutics (conjugates). Such therapeutics demonstrate improved potency in vivo due to the selective and efficient delivery to hepatocytes in the liver via receptor-mediated endocytosis, which is what drives the high interest in this molecule. The ways to synthesize such structures are relatively new and have not been optimized in terms of the yields and stages both in lab and large-scale synthesis.

Rare germline structural variants increase risk for pediatric solid tumors.

Pediatric solid tumors are a leading cause of childhood disease mortality. In this work, we examined germline structural variants (SVs) as risk factors for pediatric extracranial solid tumors using germline genome sequencing of 1765 affected children, their 943 unaffected parents, and 6665 adult controls. We discovered a sex-biased association between very large (>1 megabase) germline chromosomal abnormalities and increased risk of solid tumors in male children.

Aladyn Individual: Bayesian Hierarchical Dynamic Genetic Modeling of Comorbidity Progression.

Early identification of high-risk individuals through the analysis of their unique disease trajectories has a strong potential to support efficient prevention and clinical management across a range of chronic conditions. In this paper we present a novel approach for dynamic modeling of the evolution of chronic disease risks over time, incorporating individual genetic predispositions. Our approach uses a hierarchical Bayesian topic model including Gaussian Processes to capture age effects.