New approaches in the systematics of rickettsiae.

The development of a formal order analysis (FOA) allowed constructing a classification of 49 genomes of family representatives. Recently FOA has been extended with new tools-'Map of genes,' 'Matrix of similarity' and 'Locality-sensitive hashing'-for a more in-depth study of the structure of rickettsial genomes. The new classification confirmed and supplemented the previously constructed one by determining the position of str.

Comparison of genomes of strains using formal order analysis.

The  strain NL3262 was isolated during the Q fever outbreak in the Netherlands in 2007-2010. Formal-order analysis (FOA) was used to study the similarity of the genome (chromosome and plasmid) of this strain with the genomes from other strains. Chromosomes from ten strains and eight plasmids were studied with FOA tools such as 'Map of genes' and 'Matrix of similarity.

Approach for classification and taxonomy within family Rickettsiaceae based on the Formal Order Analysis.

Genome sequences of 36 Rickettsia and Orientia were analyzed using Formal Order Analysis (FOA). This approach takes into account arrangement of nucleotides in each sequence. A numerical characteristic, the average distance (remoteness) - "g" was used to compare of genomes.