Publications by authors named "A S Greenblatt"
Perioperative anesthetic, surgical and critical careinterventions can affect brain physiology and overall brain health. The clinical utility of electroencephalogram (EEG) monitoring in anesthesia and intensive care settings is multifaceted, offering critical insights into the level of consciousness and depth of anesthesia, facilitating the titration of anesthetic doses, and enabling the detection of ischemic events and epileptic activity. Additionally, EEG monitoring can aid in predicting perioperative neurocognitive disorders, assessing the impact of systemic insults on cerebral function, and informing neuroprognostication.
View Article and Find Full Text PDFIntracranial EEG is used for two main purposes: to determine (i) if epileptic networks are amenable to focal treatment and (ii) where to intervene. Currently, these questions are answered qualitatively and differently across centres. There is a need to quantify the focality of epileptic networks systematically, which may guide surgical decision-making, enable large-scale data analysis and facilitate multi-centre prospective clinical trials.
View Article and Find Full Text PDFArticle Synopsis
- Valid measurement of drug use in clinical trials for substance use disorder is crucial for assessing outcomes, and while self-reports are common, their accuracy varies.
- This study compared self-reports and urinalysis in a methadone treatment program and found that urinalysis often detected more drug use than participants reported, except for heroin.
- The results suggest that relying solely on self-reports could mislead findings on drug use trends, recommending the inclusion of biological tests for more accurate assessments of drug exposure in clinical trials.
Patients with drug-resistant temporal lobe epilepsy often undergo intracranial EEG recording to capture multiple seizures in order to lateralize the seizure onset zone. This process is associated with morbidity and often ends in postoperative seizure recurrence. Abundant interictal (between-seizure) data are captured during this process, but these data currently play a small role in surgical planning.
View Article and Find Full Text PDFBackground: Opioid use disorder (OUD) is associated with significant morbidity and mortality. Medication for opioid use disorder (MOUD) is a cost-effective treatment, but retention rates vary widely.
Aim: Mixed methods studies are needed to better understand how depression and pain impact the experience of OUD and MOUD treatment experiences.