Publications by authors named "A S Golovkin"
Photo-crosslinkable methacrylated alginate derivatives (M-ALGs) were synthesized modification of sodium alginate with glycidyl methacrylate. Needle (capillary) and needleless electrospinning techniques were employed to produce their nonwoven fiber mats. Spinning parameters such as applied voltage, solution composition, and flow rate were optimized to form uniform bead-free fibers with an average diameter of about 150 nm.
View Article and Find Full Text PDFCoronary artery bypass grafting (CABG) using cardiopulmonary bypass (CPB) causes a systemic inflammatory response that can worsen patient outcomes. Off-pump surgery has been associated with a reduced inflammatory response. The precise mechanisms and the role of extracellular vesicles (EVs) in this context are not fully understood.
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- The study focuses on the role of T regulatory cells (Tregs) in managing immune responses during COVID-19, highlighting their importance in controlling inflammation and immune balance throughout infection and recovery.
- Researchers analyzed Treg subpopulations in COVID-19 patients at various stages—acute infection, early recovery, and long-term convalescence—finding a significant decrease in Tregs during the acute phase, which correlated with increased inflammation and disease severity.
- After recovery, Treg levels gradually improved but did not fully return to those of healthy individuals one year later, indicating persistent immune changes, particularly in the expression of purinergic markers like CD39 and CD73.
Article Synopsis
- * The addition of CeONPs reduces fiber diameter and increases swelling and mechanical strength in the mats, while maintaining similar cell adhesion and compatibility with mesenchymal stem cells compared to standard CS-PEO mats.
- * In vivo studies showed that CS-PEO-CeONP mats had no acute toxicity or adverse inflammation and displayed slower biodegradation, indicating potential for improved healing and tissue integration over time.
There are many articles on the quantitative analysis of miRNAs contained in a population of EVs of different sizes under various physiological and pathological conditions. For such analysis, it is important to correctly quantify the miRNA contents of EVs. It should be considered that quantification is skewed depending on the isolation protocol, and different miRNAs are degraded by nucleases with different efficiencies.
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