Publications by authors named "A S Gladkikh"
The widespread use of the oral poliovaccine from Sabin strains (tOPV) radically reduced poliomyelitis incidence worldwide. However, OPV became a source of neurovirulent vaccine-derived polioviruses (VDPVs). Currently, circulating type 2 VDPVs (cVDPV2) are the leading cause of poliomyelitis.
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- - Dugbe virus (DUGV), a tick-borne virus first identified in Nigeria in 1964, has been found in several African countries and was notably detected in Senegal during the 1970s and 1980s.
- - Recent research detected three new DUGV isolates from 2877 ticks collected in the Kolda region of Senegal, indicating continued viral presence and potential unnoticed transmission in the area.
- - Phylogenetic analysis shows these new isolates are related to earlier DUGV strains in West Africa, and the study established a cost-effective method for full-genome sequencing using nanopore technology, revealing a low mutation rate and stable evolution of the virus.
Based on the success of the Sabin2-based vaccine, a next-generation nOPV2 poliovirus vaccine has been developed. For epidemic monitoring and conducting epidemiological investigations, it is necessary to have a diagnostic assay with the ability to differentiate this variant from others. Here we describe such a real-time RT-PCR assay.
View Article and Find Full Text PDFEnteroviruses (EV) are important pathogens causing human disease with various clinical manifestations. To date, treatment of enteroviral infections is mainly supportive since no vaccination or antiviral drugs are approved for their prevention or treatment. Here, we describe the antiviral properties and mechanisms of action of leucoverdazyls-novel heterocyclic compounds with antioxidant potential.
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