Publications by authors named "A S Gavrilenko"
Unlabelled: No multicenter randomized clinical trial has been conducted worldwide to date on indications, types of surgery and their comparison with conservative treatment in patients with PI BSA.
Objective: Of the study is to improve the results of surgical treatment in patients with pathological tortuosity of the internal carotid artery.
Material And Methods: The study included 119 patients (41 (34%) men and 78 (66%) women) with PI ICA aged 34 to 71 years (average age 53.
Hepatocellular carcinoma (HCC) has been associated with hepatitis C viral (HCV) infection as a potential risk factor. Nonetheless, the precise genetic regulatory mechanisms triggered by the virus, leading to virus-induced hepatocarcinogenesis, remain unclear. We hypothesized that HCV proteins might modulate the activity of aberrantly methylated HCC genes through regulatory pathways.
View Article and Find Full Text PDFComputer analysis of regulation of hepatocarcinoma marker genes hypermethylated by HCV proteins.
Vavilovskii Zhurnal Genet Selektsii
December 2022
Article Synopsis
- Hepatitis C virus (HCV) contributes to the development of hepatocellular carcinoma (HCC) through epigenetic changes, particularly aberrant DNA methylation, which serves as a potential biomarker for early diagnosis.
- The ANDSystem software identified and analyzed pathways involving 32 hypermethylated genes related to HCC, showing significant relationships in protein-protein interactions and gene expression regulations.
- HCV proteins, especially NS3, are key players in these pathways, affecting both tumor-suppressor gene regulation and transcriptional changes, highlighting potential pharmacological targets for new HCV-related therapies.
The study was designed to evaluate putative mechanisms by which lipid-associated loci identified by genome-wide association studies (GWAS) are involved in the molecular pathogenesis of coronary artery disease (CAD) using a comprehensive statistical and bioinformatics analysis. A total of 1700 unrelated individuals of Slavic origin from the Central Russia, including 991 CAD patients and 709 healthy controls were examined. Sixteen lipid-associated GWAS loci were selected from European studies and genotyped using the MassArray-4 system.
View Article and Find Full Text PDF[Surgical prevention of progressive cerebral ischemia after ischemic stroke].
Khirurgiia (Mosk)
February 2022
Objective: To evaluate the effectiveness of carotid endarterectomy after ischemic stroke and to analyze postoperative neurological status.
Material And Methods: There were 120 patients with carotid artery stenosis complicated by chronic cerebrovascular insufficiency (CVI). Patients with CVI grade I-III were included in the first group (=70), 50 patients had previous ischemic stroke (the second group).